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Laboratory for Transplantation and Regenerative Medicine

Development and deciphering mechanisms of novel therapeutic and diagnostic applications in organ transplantation and regenerative medicine
 

(PIs: Prof.Suchitra Sumitran-Holgersson, Prof. Michael Olausson and Prof. Jan Holgersson)


Organ and cell transplantations are currently the standard therapy for end-stage organ failure. However, allograft rejections, monitoring of optimal immunosuppression, and shortage of donor organs, are major problems encountered in the field.

The Sahlgrenska Transplantation Unit which is the largest organ transplant clinic in Sweden, has in 2008 made strategic recruitments of a multi-disciplinary team of highly qualified and experienced transplant surgeons and research scientists who, in close collaboration with the clinical transplantation programs, have established the Laboratory for Transplantation and Regenerative Medicine at the Sahlgrenska Academy.

The various projects we present concern:

1) Prevention of allograft rejection by improved donor-recipient selection.
2) Solve organ shortage using two new strategies - namely to avoid allograft rejection by the creation of non-immunogenic scaffolds both for allo- and xenograft rejection and the generation of endothelial and hepatic progenitor cells for transplantation.

We have introduced new specific methods to characterize and assess the importance of alloantibodies, both HLA and non-HLA-specific, as a risk factor for graft rejections. Our efforts aiming at understanding the molecular basis of xenograft rejection will continue, but will focus on delineating the immunogenicity of vascular scaffolds (vessels and heart valves) derived from pig. Such scaffolds may constitute an on-demand source of templates for tissue-engineered vascular grafts.
We have succeeded in isolating human endothelial and liver progenitor cells that not only self-proliferate ex vivo, but also functionally repopulate the damaged organs/tissues of mice with acutely injured organs.
Recently, we have been pioneering in the field of tissue-engineering, creating biocompatible blood vessels for clinical use. Experimental injury models will be used to study mechanisms of human progenitor cell migration, integration and engraftment in the injured tissues. Deciphering mechanisms of stem cell migration and engraftment will provide clinically relevant information that will make tissue repopulation with stem cells more feasible clinically. Tissue-engineered biocompatible tissues or organs using recipient’s autologous stem cells will be a major breakthrough in regenerative medicine and may help solve the organ shortage.
 

Suchitra Holgersson

 

 

 

 

 

 

 

Suchitra Sumitran-Holgersson
MSc, PhD
Professor of Transplantation Biology
tel: +46 31 3430021
mobile: +46727490808
 

Jan Holgersson

 

 

 

 

 

 

 

Jan Holgersson
MD, PhD
Professor/ Senior Physician
Clinical Chemistry and Transfusion Medicine.

Michael Olausson

Michael Olausson
MD, PhD
Professor of Transplantation

Mats Brännström

Mats Brännström
MD, PhD
Professor and Chairman
Department of Obstetrics & Gynecology
 

Contact us

Laboratory for Transplantation and Regenerative Medicine
Sahlgrenska Science Park
Medicinaregatan 8A, 2nd floor
413 46 Göteborg

 

Page Manager: Katarina Olinder Eriksson|Last update: 12/5/2012
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