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Valerio Belgrano


Valerio Belgrano

Avd för kirurgi vid Institutionen för kliniska vetenskaper (Mer information)
Sahlgrenska Universitetssjukhuset
413 45 Göteborg
Besöksadress: Blå stråket 5, vån 3 SU/Sahlgrenska , 413 45 Göteborg

Om Valerio Belgrano

Doctoral thesis - Development of individualized surgical treatments for malignant melanoma

The public defense: 2019-06-04 kl 13:00-15:30
Place: Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Supervisor: Roger Olofsson Bagge
Co-supervicor: Peter Naredi, Jonas Nilsson and Dimitrios Katsarelias
Opponent: Odysseas Zoras, University of Crete, Heraklion, Grekland
Examination board: Annika Strandell, Hans Mark och Lisbet Rosenkrantz Hølmich

NOTE The public defense will be held in English

Link to doctoral theses and short summary will be presented here on Valerio’s profile page

Combining experimental surgery and translational research for better individual treatment
Malignant melanoma is a rapidly increasing cancer, and Sweden has the 4th highest incidence in Europe, with approximately 4000 new patients yearly. Different types of melanoma are caused by different genetic mutations with different incidence, localization and clinical characteristics. Cutaneous melanoma is the most frequent encountered form. The incidence is similar worldwide between men and women, even if the localization is different. Women more often present with melanomas on the lower extremities, while it is more common with trunk melanomas in men.

- The overall aim of the thesis was to analyse the outcomes of four studies representing the ongoing evolution in clinical and experimental surgery to improve outcome for patients with melanoma, says Valerio Belgrano, PhD-student at the Department of Surgery, at Sahlgrenska Academy.

Sentinel node status, tumour thickness and ulcerated - important prognostic factors
The first paper studied the outcomes of all sentinel node* biopsies (SNB) performed at Sahlgrenska University Hospital, and this verified that the most important prognostic factors for survival, were sentinel node status, the tumour thickness and if the melanoma tumour was ulcerated.

Further the results of isolated limb perfusion (ILP) for melanoma in-transit metastasis was studied. The technique is a procedure where a limb is surgically isolated from the rest of the body, connected to a heart-lung machine, and then very high doses of a chemotherapeutic agent is perfused through the limb for one hour.

- The first study showed that in the case of recurrence it was safe to repeat the procedure. We could also show that if the treatment worked the first time, it was very likely that the patient would respond after a repeated procedure. Another question concerned the importance of BRAF-mutation as a predictive factor for response, since there were earlier conflicting results. We were able to show that BRAF-status do not affect response of the treatment.

- Finally, we created patient-derived xenograft models from 21 cutaneous melanoma biopsies transplanted into advanced mouse models and we could show that the models could be used to predict the effect immunotherapy in patients.

The conclusions are; that the surgical approach and therapies for patients with cutaneous melanoma are becoming more targeted and personalized. A specialised multidisciplinary approach can improve the understanding of the disease, support the decision-making process towards the most advantageous treatment options for each individual patient at a specific time.

*Sentinel node is, by definition, the first lymph node that drains the skin area where the primary tumor sits and is therefore the best place to selectively look for metastasis

Senaste publikationer

BRAF status as a predictive factor for response in isolated limb perfusion.
Valerio Belgrano, Jan Mattsson, Jonas A Nilsson, Roger Olofsson Bagge, Dimitrios Katsarelias
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Different Features of Tumor-Associated NK Cells in Patients With Low-Grade or High-Grade Peritoneal Carcinomatosis
S. Pesce, Valerio Belgrano, M. Greppi, S. Carlomagno, M. Squillario et al.
Frontiers in Immunology, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Response and Toxicity of Repeated Isolated Limb Perfusion (re-ILP) for Patients With In-Transit Metastases of Malignant Melanoma.
Valerio Belgrano, Jessica Pettersson, Jonas A Nilsson, Jan Mattsson, Dimitrios Katsarelias et al.
Annals of surgical oncology, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Sentinel node for malignant melanoma: An observational study of a consecutive single centre experience
Valerio Belgrano, Dimitrios Katsarelias, Jan Mattsson, Roger Olofsson Bagge
European Journal of Surgical Oncology, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Bowel vaginoplasty: a systematic review
K. Georgas, Valerio Belgrano, My Andreasson, Anna Elander, Gennaro Selvaggi
Journal of Plastic Surgery and Hand Surgery, Forskningsöversiktsartikel 2018

The effect of perfusate buffering on toxicity and response in isolated hepatic perfusion for uveal melanoma liver metastases
Ilan Ben-Shabat, Valerio Belgrano, Christoffer Hansson, Roger Olofsson Bagge
International Journal of Hyperthermia, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Isolated limb perfusion as a treatment option for rare types of tumours
Valerio Belgrano, Ilan Ben-Shabat, Peter Bergh, Roger Olofsson Bagge
International Journal of Hyperthermia, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

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